Study Type

Results of statistical analysis a

Criteria

For GWAS

Significant

P < 1x10-7

Non-significant

P > 1x10-5

Trend

1x10-7 < P < 1x10-5

For general candidate-gene association study and meta-analysis

Significant

P < 0.05 at least for one analysis

Non-significant

P > 0.05 for all analyses

For linkage analysis b [1]

Significant

LOD > 3.3 at least for one analysis

Non-significant

LOD < 1.9 for all analyses

Trend

1.9 < LOD < 3.3 for all analysis

For mutational study c

Trend

 

a: literature-origin genes with at least one significant polymorphism were defined as significant.

b: If other statistical values were used in linkage study instead of LOD, the criteria were referred to the Statistical Method in original papers.

c: Novel defined polymorphisms by mutational studies were classified as ‘Trend’ except a significant level was proposed.