Study Type 
Results of statistical analysis ^{a} 
Criteria 
For GWAS 
Significant 
P <
1x10^{7} 
Nonsignificant 
P >
1x10^{5} 

Trend 
1x10^{7}
< P < 1x10^{5} 

For general
candidategene association study and metaanalysis 
Significant 
P < 0.05
at least for one analysis 
Nonsignificant 
P >
0.05 for all analyses 

For linkage
analysis ^{b [1]} 
Significant 
LOD
> 3.3 at least for one analysis 
Nonsignificant 
LOD
< 1.9 for all analyses 

Trend 
1.9
< LOD < 3.3 for all analysis 

For mutational
study ^{c} 
Trend 

^{a}: literatureorigin genes with at least one
significant polymorphism were defined as significant.
^{b}: If other statistical values were used in
linkage study instead of LOD, the criteria were referred to the Statistical
Method in original papers.
^{c}: Novel
defined polymorphisms by mutational studies were classified as ‘Trend’ except a
significant level was proposed.